The B allele of the NS gene of avian influenza viruses, but not the A allele, attenuates a human influenza a virus for squirrel monkeys
Identifieur interne : 002142 ( Main/Exploration ); précédent : 002141; suivant : 002143The B allele of the NS gene of avian influenza viruses, but not the A allele, attenuates a human influenza a virus for squirrel monkeys
Auteurs : John J. Treanor [États-Unis] ; Mark H. Snyder [États-Unis] ; William T. London [États-Unis] ; Brian R. Murphy [États-Unis]Source :
- Virology [ 0042-6822 ] ; 1989.
English descriptors
- Teeft :
- Allele, Alternative forms, Amino, Amino acid sequence, Amino acid sequences, Amino acids, Avian, Avian influenza, Avian influenza virus, Avian influenza viruses, Avian virus, Avian viruses, Divergent evolution, Embryonated eggs, Gene, Gene segment, Gene segments, Gene sequence, Gene sequences, Homology, Human influenza, Human influenza virus, Human influenza viruses, Human virus, Human viruses, Influenza, Influenza virus, Mdck, Mdck cells, Nucleotide, Nucleotide sequence, Nucleotide sequence analysis, Nucleotide sequences, Other genes, Peak titer, Primates, Reassortant, Reassortant viruses, Reassortants, Replication, Respiratory tract, Single gene reassortant, Single gene reassortants, Squirrel, Squirrel monkeys, Virion, Virus, Virus parent, Virus parents.
Abstract
Abstract: Thenonstructural (NS) genes of avian influenza A viruses have been divided into two groups on the basis of nucleotide sequence homology, which we have referred to here as alleles A and B. We sequenced the NS genes of eight additional avian influenza A viruses in order to define the differences between these two alleles more thoroughly. Four of the viruses had NS gene sequences which resembled that of A/FPV/Rostock/34 and belonged to allele A while the other four viruses had NS gene sequences more similar to that of A/Duck/Alberta/76 and belonged to allele B. There was approximately 90% sequence homology within alleles and 72% homology between alleles. As previously reported the NS genes of human influenza A viruses belong to allele A. We constructed single gene avian-human reassortant influenza A viruses containing an allele A or B NS gene segment from an avian influenza A virus and all other genes from a human influenza A virus and tested these reassortants for their ability to grow in the respiratory tract of a nonhuman primate. Reassortants containing an avian NS gene segment of allele B were significantly restricted in growth in the respiratory tract of squirrel monkeys while reassortants with an allele A NS gene segment were not. The divergent evolution of the B NS allele in birds may have resulted in gene products which do not function optimally in cooperation with genes from a human virus in viral replication in primate respiratory epithelium.
Url:
DOI: 10.1016/0042-6822(89)90504-7
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Abstract: Thenonstructural (NS) genes of avian influenza A viruses have been divided into two groups on the basis of nucleotide sequence homology, which we have referred to here as alleles A and B. We sequenced the NS genes of eight additional avian influenza A viruses in order to define the differences between these two alleles more thoroughly. Four of the viruses had NS gene sequences which resembled that of A/FPV/Rostock/34 and belonged to allele A while the other four viruses had NS gene sequences more similar to that of A/Duck/Alberta/76 and belonged to allele B. There was approximately 90% sequence homology within alleles and 72% homology between alleles. As previously reported the NS genes of human influenza A viruses belong to allele A. We constructed single gene avian-human reassortant influenza A viruses containing an allele A or B NS gene segment from an avian influenza A virus and all other genes from a human influenza A virus and tested these reassortants for their ability to grow in the respiratory tract of a nonhuman primate. Reassortants containing an avian NS gene segment of allele B were significantly restricted in growth in the respiratory tract of squirrel monkeys while reassortants with an allele A NS gene segment were not. The divergent evolution of the B NS allele in birds may have resulted in gene products which do not function optimally in cooperation with genes from a human virus in viral replication in primate respiratory epithelium.</div>
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